If you’ve been hearing a lot about GLP-1 medications lately, you’re not alone. Many of my clients come to me feeling curious but cautious… especially when they see the word “compounded” thrown around. They want to lose weight, support their metabolism, or manage blood sugar, but they also want to do it safely.
And the truth is, not all compounded GLP-1s are created equal.
Choosing the right provider isn’t just about cost. It’s about knowing what you’re putting in your body, who you’re trusting with your health, and what kind of support you’re going to get along the way.
Let’s break it all down.
What Are Compounded GLP-1s?
GLP-1 medications like Ozempic® and Wegovy® are designed to mimic a hormone that helps regulate appetite, blood sugar, and insulin levels. But those brand-name options can be expensive, hard to find, or not covered by insurance.
That’s where “compounded” versions come in. These are custom-made versions of the medication, often prepared by a licensed compounding pharmacy.
They’re typically more affordable and accessible. But—and this is important—compounding is only legal and safe when it’s done under the right circumstances.
When Compounding Is Legal (and When It’s Not)
Right now, compounding is only allowed when there’s an active shortage of the brand-name medication. Pharmacies that prepare these compounds must be either 503A (serving individual patients) or 503B (outsourcing facilities regulated by the FDA).
If a brand-name GLP-1 is no longer in shortage, compounding it may no longer be considered legal. That’s a big deal, especially with new FDA guidance expected in 2025.
So if a provider is offering compounded versions without a clear explanation of the pharmacy or shortage status, that’s a red flag.
Red Flags to Watch Out For
Here are a few things I tell my clients to avoid:
- No medical intake or telehealth consultation
- No mention of which pharmacy is used
- Pricing that seems too good to be true
- No support after purchase
These signs often mean the provider is cutting corners—and that could impact your health.
What to Look for in a Legitimate Provider
If you’re considering compounded GLP-1s, make sure the provider:
- Uses a licensed U.S.-based pharmacy (503A or 503B)
- Requires a medical evaluation and approval from a licensed clinician
- Is transparent about ingredients, dosages, and shipping
- Offers follow-up support, not just a one-time transaction
- Educates patients on side effects, dose titration, and realistic expectations
Bonus points if they talk about things like microdosing, step-up protocols, or longevity-based approaches. It shows they know what they’re doing.
Telemedicine vs. Primary Care vs. Local Medspas: What’s the Best Route?
| Option | Pros | Cons |
|---|---|---|
| Telemedicine | Convenient, discreet, often more affordable. Many offer ongoing support. | Quality varies. You must vet the provider and pharmacy. |
| Your Doctor | Knows your medical history, can bill insurance. | May not prescribe GLP-1s unless you meet strict criteria. |
| Medspa or Clinic | Face-to-face consults, possible quick start. | Not all are licensed to prescribe or compound safely. Ask questions. |
Jennifer’s take: All three can work — if done responsibly. But no matter which route you take, always ask where the medication comes from, who approves it, and what support you’ll get afterward.
Note: See our top-rated GLP-1 telemedicine providers, based on my research and what my clients recommend amongst each other.
Questions to Ask Before You Commit
Arm yourself with the right questions:
- Where is my medication coming from?
- Is a licensed provider reviewing my health history?
- What happens if I have side effects or need to adjust my dose?
- Is this compounded version still legal under current FDA guidance?
If they dodge those questions, move on.
Practical Steps to Take Before You Order
- Write down your health goals.
Are you looking for weight loss, blood sugar support, or long-term wellness? - Make a list of questions to ask.
Use the list above to guide your research — pharmacy, approval process, side effect support. - Compare at least 2–3 providers.
Don’t jump at the first ad you see. Transparency and support matter. - Check for current FDA guidance.
Make sure the compounded option is still compliant under the current shortage status. - Track how you feel if you start.
Side effects, cravings, hunger — take notes and advocate for yourself.
A Final Word From Me
I know it can feel overwhelming. When you’re trying to take care of your body, the last thing you need is confusion or uncertainty.
But asking questions doesn’t make you high-maintenance. It makes you smart.
Compounded GLP-1s can be a powerful part of a longevity-focused plan when used responsibly and prescribed by the right people. Just be sure you know where they’re coming from—and that you’re not alone on the journey.
Because at the end of the day, it’s not just about losing weight. It’s about feeling strong, supported, and in control of your health.